EDEM, Edinburgh, UK, a company that offers discrete element method (DEM) technology for bulk and granular material simulation, has partnered with leading organizations and experts from industry and academia to understand common problems and practices in powder calibration and comprehend the latest research advances in the field. The company also hosted a meeting on “DEM Powder Calibration” in 2018, which involved various stakeholders from the pharmaceutical industry and researchers from universities as well as powder testing equipment providers Freeman Technology and GranuTools. As a result of these investigations and meetings, EDEM has released a technical report that discusses the latest challenges and advances in powder simulation as well as providing guidelines for calibration. The document is available at www.edemsimulation.com. The technical report covers several key topics including factors affecting particle behavior, standard calibration methodology, criteria for designing suitable calibration tests, and critical factors per application area. The report also describes the most common calibration tests available.