PowderBulk.com
is available for sale
About PowderBulk.com
Former domain of a monthly technical publication exclusively for readers in the North American powder and bulk solids market.
Exclusively on Odys Marketplace
$6,460
What's included:
Domain name PowderBulk.com
Become the new owner of the domain in less than 24 hours.
Complimentary Logo Design
Save time hiring a designer by using the existing high resolution original artwork, provided for free by Odys Global with your purchase.
Built-In SEO
Save tens of thousands of dollars and hundreds of hours of outreach by tapping into the existing authority backlink profile of the domain.
Free Ownership Transfer
Tech Expert Consulting
100% Secure Payments
Premium Aged Domain Value
Usually Seen In
Age
Traffic
SEO Metrics
Own this Domain in 3 Easy Steps
With Odys, buying domains is easy and safe. Your dream domain is just a few clicks away.
.1
Buy your Favorite Domain
Choose the domain you want, add it to your cart, and pay with your preferred method.
.2
Transfer it to your Registrar
Follow our instructions to transfer ownership from the current registrar to you.
.3
Get your Brand Assets
Download the available logos and brand assets and start building your dream website.
Trusted by the Top SEO Experts and Entrepreneurs
Rachel Parisi
★ ★ ★ ★ ★
I purchased another three aged domains from Odys in a seamless and painless transaction. John at Odys was super helpful! Odys is my only source for aged domains —you can trust their product.
Stefan
★ ★ ★ ★ ★
Odys is absolutely the best premium domain marketplace in the whole internet space. You will not go wrong with them.
Adam Smith
★ ★ ★ ★ ★
Great domains. Great to deal with. In this arena peace of mind can be difficult to come by, but I always have it with Odys and will continue to use them and recommend them to colleagues and clients.
Brett Helling
★ ★ ★ ★ ★
Great company. Very professional setup, communication, and workflows. I will definitely do business with Odys Global moving forward.
Larrian Gillespie Csi
★ ★ ★ ★ ★
I have bought 2 sites from Odys Global and they have both been of high quality with great backlinks. I have used one as the basis for creating a new site with a great DR and the other is a redirect with again high DR backlinks. Other sites I have looked through have low quality backlinks, mostly spam. I highly recommend this company for reliable sites.
Henry Fox
★ ★ ★ ★ ★
Great company!
Vijai Chandrasekaran
★ ★ ★ ★ ★
I’ve bought over 30 domains from Odys Global in the last two years and I was always very satisfied. Besides great quality, niche-specific auction domains, Alex also helped me a lot with SEO and marketing strategies. Auction domains are not cheap, but quality comes with a price. If you have the budget and a working strategy, these domains will make you serious money.
Keith
★ ★ ★ ★ ★
Earlier this year, I purchased an aged domain from Odys as part of a promo they’re running at the time. It was my first experience with buying an aged domain so I wanted to keep my spend low. I ended up getting a mid level DR domain for a good price. The domain had solid links from niche relevant high authority websites. I used the site as a 301 redirect to a blog I had recently started. Within a few weeks I enjoyed new traffic levels on my existing site. Happy to say that the Odys staff are friendly and helpful and they run a great business that is respected within the industry.
Micronization in the pharmaceutical industry
Fred Surville, Jet Pulverizer
Micronization is the process of reducing a bulk solid material’s particle size to the micron or submicron level. This article discusses dry powder milling techniques and their effectiveness for micronization, specifically in the pharmaceutical industry. The article looks at how mechanical, ball, and jet mills stack up against each other.
Studies have linked micronization with the increased bioavailability of active pharmaceutical ingredients since the early 1980s.1 Simply put, finer particles increase a material’s surface area, which increases bioavailability, especially in poorly soluble materials.2 Since then, considerable research has evaluated the effects of different types of milling on micronization. These studies, however, typically include wet-milling techniques, which skew the findings. While wet milling does tend to create finer particles, it also increases costs and steps and adds many variables that dry milling doesn’t include.
Mill types
Different types of mills have pros and cons when trying to size-reduce material to the micron and submicron level.
Mechanical mills. Hammermills or pin mills are usually the first mills that pharmaceuticals, cosmetics, or sanitary materials manufacturers consider when evaluating techniques for particle size reduction. Basically, these mills have hammers or pins that rotate and strike the material particles. The design, as well as the number of pins or hammers, varies with the application. Well-designed, high-speed mechanical mills can grind some friable materials to a low-micron size. Practically speaking, a commercial hammermill can obtain a particle size of 200 mesh (74 microns), with a typical mid-range particle size of 80 mesh (177 microns).
Equipment wear and material contamination, however, are serious problems when using a high-speed mechanical mill, as is attritional heat. Contamination is an issue in most product applications and can be very acute in pharmaceutical manufacturing. Ingredients can seriously erode hammermills, adding metallic contamination to the product. Bulk solids materials that degrade with heat or have low melting temperatures also are a problem for hammermills because the mills generate heat, typically reaching temperatures above 90°C (194°F). Materials such as active pharmaceutical ingredients and pharmaceutical excipients that have lower melting temperatures or are prone to heat degradation are usually not great candidates for mechanical milling.
Ball mills. Ball mills tend to be the least expensive and most obvious micronization option, especially for pharmaceutical research and development. The use of ball milling as a micronization technique for enhancing drug solubility has been well supported by literature as far back as the 1970s.
Ball mills micronize material by agitating it in a vessel using steel or ceramic balls or other media. Apart from ball milling’s comminution function, the technique also serves as an intensive mixing technique capable of producing co-ground, pharmaceutical-excipient mixtures comprising amorphous drug forms mixed with suitable hydrophilic excipients at the molecular level.3
Milling is always a function of residence time in the mill, but ball mills are especially sensitive to residence time and can create long batch processes. Ball mills equipped with a classifier can produce a finely sized product, but the particle size distribution (PSD) tends to be very wide. By the time this type of mill achieves the correct average particle size, the number of fines is usually too high (above 10 percent). Mill suppliers can line ball mills with ceramics to reduce contamination from abrasive materials, but mill media wear is constant, which also can contaminate a product.
Jet mills. Until the introduction of jet mills in 1936, dry grinding in the subsieve range of 625 mesh (20 microns) to 2,500 mesh (5 microns) was impractical. To create fine particles with a narrow PSD, manufacturers previously had to mill the material, sieve out the oversized particles, and re-mill. The process was long, expensive, and inefficient.
Jet mills can mill materials to single-digit micron particle sizes in a single pass, increasing yield and operational efficiencies, as shown in the graphs in Figure 1. Figure 1a. shows ball-milled material’s PSD, while 1b. shows a jet-milled material. In this micronization method, the mill injects high-velocity, compressed air into a chamber where a rate-controlled feeder adds the starting raw materials. As the particles enter the airstream, they accelerate and collide with each other and the milling chamber’s walls at high velocities. Particle size reduction occurs through a combination of impact and attrition. Impacts arise from the collisions between the rapidly moving particles and between the particles and the wall of the milling chamber. Attrition occurs at particle surfaces as particles move rapidly against each other, resulting in shear force that can break up the particles.